Cancer of the female lower genital tract

Cancer of the female genital tract.

• More than 71,000 women in the United States were diagnosed with a cancer affecting the reproductive organs. • More than 27,000 women in the United States died from some form of gynecologic cancer. • Uterine (endometrial) cancer is the most common gynecologic cancer. • Ovarian cancer is the most deadly gynecologic cancer. • Cervical cancer was once the leading cause of death for women in the U...

Polypoid lesions of the lower female genital tract.

A 46-year-old multiparous (gravida 3, para 3) woman presented to her primary care provider with a palpable vulvar polypoidal mass, measuring 7 cm in greatest dimension. The mass was painless and had been growing in size over the past 2 years. Her medical history was remarkable for obesity, hypothyroidism, and an appendectomy at age 17. Her family history was significant for a sister with breast...

The Pathobiology of Neisseria gonorrhoeae Lower Female Genital Tract Infection

Infection and disease associated with Neisseria gonorrhoeae, the gonococcus, continue to be a global health problem. Asymptomatic and subclinical gonococcal infections occur at a high frequency in females; thus, the true incidence of N. gonorrhoeae infections are presumed to be severely underestimated. Inherent to this asymptomatic/subclinical diseased state is the continued prevalence of this ...

Deregulated Apoptosis in Female Genital Tract Cancer

Apoptosis is initiated via the mitochondrial or the death receptor pathway. Central to the mitochondrial pathway is the release of cytochrome c from the mitochondria, leading to activation of the caspase cascade and execution of apoptosis.1 The mitochondrial pathway is regulated by the BCL-2 family of proteins, i.e. proapoptotic BAX and BAK as well as antiapoptotic BCL-2 and BCL-xL. The death r...

Female Genital Tract Tumors